Repricing A Sub-Optimally Priced Niche Biologic—Specialty Pharma

A small specialty pharma company had a category-leading product that it had acquired several years earlier but which had limited profitability.  Importantly, to expand use, the company would need to make large investments in plant capacity, manufacturing, and R&D.  The existing product pricing did not provide a significant margin, considering the costs to produce the complex product, to support needed investments in manufacturing.

The Vice President of Sales and Marketing engaged BMI to assess re-pricing the product.

BMI Approach

BMI came to the project with a breadth of experience in pricing research and pricing implementation, market access (which informs pricing) and previous experience in the key markets of relevance to our client’s project.  This allowed us to be a highly valued thought partner throughout the process and to drive change in an otherwise risk-averse organization.

BMI conducted a multi-step project, helping our client to successfully realize a new price:

Step 1: Assess Customer Price Sensitivity and Elasticity

BMI sought to answer the following questions for the client’s product:

  • The level of price awareness (current price)
  • The perception of current price and product value (at that price)
  • The impact of potential price increases on product perception, value, and use (among different customer segments)
  • Payer receptivity to pricing changes, including risks (in the form of suboptimal formulary placement and/or prior authorization criteria)
  • The financial impact of pricing changes on different customer segments, patients and payers
  • The impact of any pricing change on existing GPO and managed care contracts, Medicaid rebates and 340B price

To assess the above, BMI conducted extensive primary (qualitative and quantitative) and secondary research including:

  • In-depth interviews and surveys with prescribing audiences (clinicians using the product in different settings) and influencers of prescribing (hospital administrators, hospital pharmacy directors)
  • Interviews with a range of decision-makers at managed care organizations, including pharmacy directors with P&T responsibility and policy-making roles
  • Evaluation of “comps”, including similar situations where a product was “re-priced”

Based on the research, BMI created a model analyzing the impact of different price increases, by customer segment, including setting (e.g., outpatient, inpatient, long-term care), which allowed the client to understand optimal pricing and potential impacts on specific segments.

Step 2: Implementing the New Price

Based on BMI’s assessment and recommendations, the client decided to re-price the product.  BMI and the client introduced the research and rationale for the increase internally and developed talking points for the field force and for the corporation.  An education session was held with the company’s sales and marketing team introducing the new price and the strong research supporting the effort.

BMI conducted a payer advisory board for insights on how to position the price increase to managed care organizations, as well as how to mitigate any negative consequences on payers and providers.

Step 3: Monitoring Reaction and Responding to Concerns

BMI worked with the client to set up a process to evaluate the market reaction to the new price and to respond to any concerns with the new pricing.

Results

The re-pricing was extremely successful.  BMI’s research was key to understanding the impact of the price increase and BMI played an important role in getting internal buy-in to the new price and implementing the increase in the field with limited customer impact or changes in managed care coverage.  Importantly, the client, with greater profitability, was able to make further needed investments in the brand.

Contact

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Elizabeth K. Brooks, Partner, San Francisco 

Ms. Brooks has worked in market research and health care policy for 30 years. During this time, she has helped biotechnology, pharmaceutical, and medical device companies develop marketing, reimbursement, distribution, and overall launch strategies for their products.  Ms. Brooks has analyzed markets for, and provided due diligence support on, hundreds of therapeutics.  She is also expert at reimbursement issues, offering analysis, education, and tactical support to pharmaceutical and biotechnology concerns, as well as medical device companies. In addition, Ms. Brooks has developed a model for helping companies evaluate the need for pharmacoeconomic studies and has trained hundreds of staff on the appropriate use of outcomes research tools.  Ms. Brooks holds a Masters of Business Administration and an Honors Bachelor of Arts degree in English, both from the University of Chicago. She also earned a Certificate from the University of Chicago Graduate Program on Health Administration and Policy.

Elizabeth K. Brooks, Partner, San Francisco 

Ms. Brooks has worked in market research and health care policy for 30 years. During this time, she has helped biotechnology, pharmaceutical, and medical device companies develop marketing, reimbursement, distribution, and overall launch strategies for their products.  Ms. Brooks has analyzed markets for, and provided due diligence support on, hundreds of therapeutics.  She is also expert at reimbursement issues, offering analysis, education, and tactical support to pharmaceutical and biotechnology concerns, as well as medical device companies. In addition, Ms. Brooks has developed a model for helping companies evaluate the need for pharmacoeconomic studies and has trained hundreds of staff on the appropriate use of outcomes research tools.  Ms. Brooks holds a Masters of Business Administration and an Honors Bachelor of Arts degree in English, both from the University of Chicago. She also earned a Certificate from the University of Chicago Graduate Program on Health Administration and Policy.

Paul C. Nagle, Partner, San Francisco

Mr. Nagle has advised medical product manufacturers on a wide range of strategic issues for over 30 years. He specializes in market assessments, payer and reimbursement strategy, and pricing and contracting strategy. With his thorough knowledge of payer policies, he has helped dozens of product manufacturers understand and penetrate managed care, Medicare, and Medicaid segments, as well as provider segments when they are de facto payers. He also frequently conducts due diligence for M&A and licensing opportunities for manufacturers and the investment community. Mr. Nagle performs pricing analyses and develops contracting strategies (including multiple product contracting) using a variety of methodologies. Mr. Nagle also has significant expertise in international market assessments.  Mr. Nagle is frequently called upon by his clients to research, analyze and strategize about particularly unique and challenging manufacturer dilemmas and novel areas of interest.  Mr. Nagle holds a Bachelor of Science in Business Administration from the Olin School at Washington University in St. Louis.

Paul C. Nagle, Partner, San Francisco

Paul C. Nagle for over 30 years, Mr. Nagle has advised medical product manufacturers on a wide range of strategic issues. He specializes in pricing strategy, payer and reimbursement strategy, and assessing markets and products for licensing and M&A due diligence. Mr. Nagle’s focus is most frequently on the US and Europe, but also includes Japan and Brazil. He frequently consults to the investment community for opportunities under consideration. Mr. Nagle performs pricing analyses and develops pricing and contracting strategies using a variety of methodologies. Mr. Nagle also has significant expertise in third-world market assessments. Mr. Nagle is frequently called upon by his clients to research, analyze and strategize about particularly unique and challenging manufacturer dilemmas and novel areas of interest. Additionally, Mr. Nagle has helped state Medicaid programs and private payers understand the impact of specialty products, and his analyses have impacted Medicare legislation. Mr. Nagle holds a Bachelor of Science in Business Administration from the Olin School at Washington University in St. Louis. Before co-founding BioMedical Insights, Mr. Nagle was at Health Technology Associates, which became part of Covance.

Christopher A. Nicita, Partner, San Francisco

Mr. Nicita specializes in market and technology assessment, new product planning, and pricing and reimbursement strategy. He has over 30 years of experience in health care market analysis and medical research. Mr. Nicita has helped identify and evaluate opportunities afforded by dozens of new products, technologies, and markets and has helped the firm’s clients develop and launch a number of innovative new therapies. He has worked with a range of companies, from industry leaders to start-ups, to make sound portfolio investment decisions and to optimize clinical development strategy. Mr. Nicita frequently consults to companies on prospective in-licensing and merger and acquisition candidates, and has provided due diligence services to a variety of health care investors. He has broad expertise in most therapeutic classes and disease areas including oncology, infectious diseases, immune-mediated and inflammatory diseases, endocrinologic diseases, ultra rare genetic diseases, and cardiovascular diseases, among others. Mr. Nicita holds a Masters of Business Administration and an Honors Bachelor of Science in Molecular Biology, both from the University of Michigan.

Christopher A. Nicita, Partner, San Francisco

Mr. Nicita specializes in market and technology assessment, new product planning, and pricing and reimbursement strategy. He has over 30 years of experience in health care market analysis and medical research. Mr. Nicita has helped identify and evaluate opportunities afforded by dozens of new products, technologies, and markets and has helped the firm’s clients develop and launch a number of innovative new therapies. He has worked with a range of companies, from industry leaders to start-ups, to make sound portfolio investment decisions and to optimize clinical development strategy. Mr. Nicita frequently consults to companies on prospective in-licensing and merger and acquisition candidates, and has provided due diligence services to a variety of health care investors. He has broad expertise in most therapeutic classes and disease areas including oncology, infectious diseases, immune-mediated and inflammatory diseases, endocrinologic diseases, ultra rare genetic diseases, and cardiovascular diseases, among others. Mr. Nicita holds a Masters of Business Administration and an Honors Bachelor of Science in Molecular Biology, both from the University of Michigan.

Andrew P. Kloek, Ph.D., Principal, Nashville

Dr. Kloek has worked in market research, reimbursement and technology assessment with BioMedical Insights since 2007. He holds a Bachelor’s degree in Genetics and Chemistry from Western Kentucky University and a Ph.D. in Genetics from Washington University in St. Louis. Prior to joining BioMedical Insights, he spent eight years with biotechnology start-up companies including three years working with Affymetrix-based micro-array technologies at Perlegen Sciences, a Mountain View, California-based company focused on pharmacogenomics and personalized medicine. He has co-authored 20 peer-reviewed scientific publications and 10 issued patents in the fields of genetics and biotechnology.

Andrew Kloek, Ph.D., Principal, Nashville

Dr. Kloek has worked in market research, reimbursement and technology assessment with BioMedical Insights since 2007. He holds a Bachelor’s degree in Genetics and Chemistry from Western Kentucky University and a Ph.D. in Genetics from Washington University in St. Louis. Prior to joining BioMedical Insights, he spent eight years with biotechnology start-up companies including three years working with Affymetrix-based micro-array technologies at Perlegen Sciences, a Mountain View, California-based company focused on pharmacogenomics and personalized medicine. He has co-authored 20 peer-reviewed scientific publications and 10 issued patents in the fields of genetics and biotechnology.

Jacqueline D. Koenig, Principal, Houston

Ms. Koenig has been with BioMedical Insights since 2004. She helps life sciences and medical device companies conduct due diligence, analyze market nuances, assess licensing and investment opportunities, prioritize clinical indications, and create market access strategies across numerous therapeutic categories. Prior to joining BioMedical Insights, Jacqui worked at the Kaiser Family Foundation developing national public education campaigns and conducting public opinion and provider surveys. She started her career at what is now Covance (formerly Health Technology Associates). Ms. Koenig holds a Bachelor of Arts degree in Economics from Vassar College and a Master of Science in Business degree from Johns Hopkins University.

Jacqueline Koenig, Principal, Houston

Ms. Koenig has been with BioMedical Insights since 2004. She helps life sciences and medical device companies conduct due diligence, analyze market nuances, assess licensing and investment opportunities, prioritize clinical indications, and create market access strategies across numerous therapeutic categories. Prior to joining BioMedical Insights, Jacqui worked at the Kaiser Family Foundation developing national public education campaigns and conducting public opinion and provider surveys. She started her career at what is now Covance (formerly Health Technology Associates). Ms. Koenig holds a Bachelor of Arts degree in Economics from Vassar College and a Master of Science in Business degree from Johns Hopkins University.